News & updates
06 April 2019
Kai Johnsson’s lab, in collaboration with Spirochrome, developed a new concept of photoactivatable fluorophore for single molecule localization microscopy in live cells: PA-SiR.
The preprint is online on BioRxiv
PA-SiR fluorescence can be turned on by UV-light (e.g. a 405 nm laser), forming a bright silicon rhodamine fluorophore emitting in the far-red. The mechanism of photoconversion is unprecedented and involves a photoinduced proton transfer. As the photoconversion is intrinsic to the molecule, no caging group is needed to switch to the fluorescent form, making the fluorophore cell permeable and bio-compatible.
02 April 2019
Our live cell actin probe SiR-actin took a space flight in the International Space Station (ISS). Cora Thiel et al. built a miniaturized SIM microscope and imaged live and fixed cells stained with SiR-actin in the ISS. Congratulations to the authors.
Read the article here
04 March 2019
Our fluorescent membrane tension probe Flipper-TR® is now available at our distributors Cytoskeleton, Inc (north America) and Tebu-bio (Europe without CH).
23 January 2019
Spirochrome is proud to support the 11th Conference of the International PhD Program in Life Sciences.
The conference, organized by graduate students, is designed to initiate and promote scientific discussion and networking within the Swiss and wider life sciences community.
07 January 2019
Happy New year!
Spirochrome wishes you a happy and very successful 2019.
Follow us on Twitter and find out the latest information about our products and the coming ones.
2019 will be colorful!
27 November 2018
Flipper-TR: the first fluorescent live cell fluorescent membrane tension probe is now available from Spirochrome
06 January 2017
Spirochorme introduces the new SiR-reagent SiR-BCN for click chemistry with tetrazine and azide derivatives.
05 September 2016
Spirochrome proudly launches the brand new and further red emitting SiR700 probes for actin, DNA and microtubules. SiR700 probes allow dual colour imaging experiments in live cells and dual colour superresolution imaging with STED and SIM. In addition, two new fluorogenic live cell probes for lysosomes are introduced: SiR-lysosome and SiR700-lysosome. The probes were published by the Johnsson group in JACS: http://pubs.acs.org/doi/abs/10.1021/jacs.6b04782.
26 July 2016
Soon available at Spirochrome: A new SiR-probe for lysosomes and four brand new red shifted SiR-probes for actin, tubulin, DNA and lysosomes for dual colour imaging in live cells: http://pubs.acs.org/doi/abs/10.1021/jacs.6b04782
22 July 2016
The European Patent Office grants the patent based on the patent application WO2013029650 covering carboxylated silicon rhodamine derivatives and probes within the European territory, of which Spirochrome is the exclusive licensee.
4 May 2016
The US patent office grants the US patent US9346957 covering on the US territory carboxylated Silicon Rhodamine derivatives. Spirochrome is the exclusive licensee.
5 October 2015
Spirochrome further expands its products portfolio and launches three new SiR-reagents: SiR-alkyne, SiR-azide and SiR-tetrazine. These reagents allow bioortogonal click chemistry.
1 October 2015
Spirochrome launched its new probe SiR-DNA. SiR-DNA is a far-red, cell permeable, non-toxic probe for DNA.
25 May 2015
Spirochrome has appointed Cytoskeleton, Inc. as its exclusive distributor for the probes SiR-actin kit, SiR-tubulin kit and Cytoskeleton kit in North America (US and CA). Customers from these countries can now find and order our probes from Cytoskeleton, Inc. here
12 Feruary 2015
Since February 2015, Verapamil, an efflux pump inhibitor, is included free of charge with every order of SiR-actin, SiR-tubulin or Cytoskeleton kit. Verapamil has been sown to enhace the uptake of SiR-probes on living cells Read more. The products SC001 SiR-actin and SC002 SiR-tubulin have therfore been renamed “SiR-actin kit” and “SiR-tubulin kit”.
19 January 2015
Leica and Spirochrome released the application note “A Bright Dye for Live-Cell STED Microscopy” exemplifying the enormous power of the combination of SiR-based probes and STED nanoscopy.
July 2014
Spirochrome was granted by EPFL an exclusive license from the patent application WO2013029650 to exclusively commercialize Silicon Rhodamine derivatives and probes.