About Spirochrome
Imaging of biological structures within living cells has become an indispensable tool in modern research. Unlike traditional immunostaining of fixed cells, live-cell fluorescence microscopy demands specialized fluorescent reporters capable of functioning within living systems. These reporters must effectively label cells either by traversing cellular membranes or by being expressed and assembled within the cell, as with fluorescent proteins.
Spirochrome is at the forefront of innovation in live-cell imaging, offering the scientific community unparalleled tools to visualize and study dynamic biological processes in real time. Our mission is to empower researchers with cutting-edge fluorescent probes that enable precise and reliable imaging of living cells, advancing the boundaries of cellular biology.
Specializing in live-cell fluorescence microscopy, we develop and provide a unique portfolio of fluorescent probes designed for simplicity and high reliability. Complementary to traditional methods that rely on fluorescent protein tagging, our solutions allow for the imaging of live cells with minimal disruption, ensuring that the biological integrity of the cells remains intact. Our products are meticulously engineered to integrate seamlessly into your workflow, often only requiring a minimal “add and image” protocol, thereby streamlining the process and saving valuable time.
At Spirochrome, we are committed to continuous innovation. Our team is dedicated to the ongoing development of novel fluorophores, probes and advanced imaging tools that meet the evolving needs of live cell imaging. By combining scientific excellence with practical application, Spirochrome is proud to contribute to breakthroughs in understanding cellular processes and disease mechanisms.
Whether you are exploring cellular dynamics, investigating disease models, or developing new therapies, Spirochrome provides the reliable, high-quality imaging tools you need to bring your research forward.
Our technology
Spirochrome’s technology is founded on the innovative application of small molecule probes and proprietary organic fluorophores. Our approach integrates highly photostable, fluorogenic, and cell-permeable fluorophores with ligands that are meticulously engineered to target subcellular compartments and organelles with high specificity. The resulting probes deliver exceptional fluorescence intensity alongside precise subcellular localization.
Our probes enable rapid staining, with incubation times ranging from mere minutes to a few hours. This eliminates the need for laborious genetic manipulations to express fluorescent proteins, which can be both time-intensive and, in certain cases, impractical due to limitations such as low expression and slow maturation within cells.
All of our probes are tested for the absence of toxicity, guaranteeing minimal perturbation of the cell upon incubation at functional concentrations.
Spirochrome’s portfolio spans the entire visible and far-red spectrum, ensuring compatibility with a wide array of fluorescence microscopy systems and multicolor imaging. Our probes are at the forefront of high-performance fluorescent imaging, offering unparalleled quality and reliability for advanced biological research.
