Our new SPY620 probes are here!
We are proud to introduce our new red emitting SPY™ probes based on Map618 fluorophore developed by the Johnsson group in Heidelberg.1)
SPY620-actin is a highly fluorogenic probe for F-actin with a turn-on ratio above 400 fold upon actin binding.
SPY620-DNA is a bright probe for nuclear staining.
Both DNA and actin probes work on live and fixed cells.
We also introduce the SNAP-tag substrate SPY620-BG for SNAP-tag* labeling inside living cells.
1. “A general strategy to develop cell permeable and fluorogenic probes for multicolour nanoscopy”; Lu Wang, et. al.; Nature Chemistry 12, 165-172, 2020.
Image: live Cos7 cells labeled with SPY620-actin. Courtesy of N. Schilling, D. Haenni & U. Ziegler; Center for Microscopy and Image Analysis; University of Zurich Switzerland.
*SNAP-tag™ is a registered trademark of New England Biolabs, Inc.
