Coming Soon: CenSpark650 the first centriole and cilia selective probe.

Coming Soon: 

CenSpark650 the first centriole and cilia selective probe.

CenSpark650, a dual-ligand fluorescent probe for centrioles and cilia selective imaging.

Visualizing centrioles and cilia in live cells was only available through complex genetic engineering. To overcome this limitation, we are proud to announce the upcoming release of CenSpark650, a transformative small-molecule probe designed for the selective visualization of centriolar and axonemal microtubules.

CenSpark650 exploits a unique structural feature: the juxtaposition of inner and outer microtubule-binding sites found exclusively in the microtubule triplets and doublets of centrioles and cilia.  CenSpark650 achieves unprecedented selectivity in both live and fixed specimens across diverse eukaryotic systems.

This novel tool enables researchers to:

– Track centriole dynamics in live cells over extended periods with negligible toxicity.

– Visualize primary and motile cilia without the need for genetic manipulation, making it ideal for difficult-to-transfect cells and non-model organisms.

– Monitor rapid cellular events, such as centrosome polarization at the immunological synapse in CAR-T cells, with superior spatial resolution.

Discover how CenSpark650 can revolutionize your cell biology research. Read the full study published in Nature Chemical Biology: https://doi.org/10.1038/s41589-026-02186-1